Carlisle United are 16/5 to claim an FA Cup victory today at the ground where Paul Simpson's second reign started.

The Blues head to Leyton Orient's Brisbane Road for this afternoon's first round tie.

Bookmaker Midnite offer the best odds for a Carlisle win in east London, with other victory prices including 3/1 with SkyBet and 29/10 with William Hill.

Richie Wellens' Orient, who won at Brunton Park three weeks ago in the league, are odds-on with some bookies to claim another win on home soil this afternoon.

William Hill make the Os 10/11 to prevail with Unibet offering 19/20.

A draw, which would lead to a Brunton Park replay, is 12/5.

Ruel Sotiriou, who hit the only goal when the sides last met, is 13/2 to get the opener again for Orient.

For Carlisle, Joe Garner is 10/1 to strike first with Sean Maguire 11/1.

Longer shots for the opener in a United shirt include top scorer Jordan Gibson at 16/1, Owen Moxon at 22/1, Jon Mellish at 28/1 and Ben Barclay at 50/1.

Orient first scorer prices, meanwhile, include Joe Pigott at 6/1, Theo Archibald at 10/1, Idris El Mizouni at 14/1 and Dan Happe at 40/1.

Carlisle are 9/1 for a repeat of the 1-0 win that heralded Simpson's second coming back in February 2022.

The same score in Orient's favour - the result on United's visit last season when a Mellish own-goal saw the hosts win - is 5/1.

Carlisle and the Os have only met once before in the FA Cup, back in the second round in 1936, with the Cumbrians defeating the then named Clapton Orient 4-1.

A similarly heavy United win this afternoon is 200/1.

Source: Oddschecker.