Carlisle United's next opponents Grimsby Town have pulled off a major upset in the FA Cup - knocking out Premier League side Southampton.

Three days before the Mariners head to Brunton Park in League Two, they stunned the Saints at St Mary's in the fifth round.

Two penalties from Gavan Holohan were enough to clinch a memorable 2-1 win, with Duje Caleta-Car's Southampton strike proving a consolation.

It sent Paul Hurst's Grimsby - 16th in the fourth tier - through to the quarter-finals for the first time since 1939.

News and Star: Grimsby's Anthony Driscoll-Glennon in a fish mask after the gameGrimsby's Anthony Driscoll-Glennon in a fish mask after the game (Image: PA)

They will now face another away tie against top-flight opposition in Brighton & Hove Albion.

Grimsby had already seen off higher-league opposition in each round on their way to the last 16, defeating Plymouth Argyle, Cambridge United, Burton Albion and Luton Town.

They then became the first side ever to defeat five sides from a higher level in one season in the cup.

They shocked Ruben Selles' Saints when they were awarded a penalty by VAR in first-half added time after Joshua Emmanuel's cross struck Lyanco's arm, and former Hartlepool United man Holohan slotted home.

News and Star: Gavan Holohan celebrates his second penalty which proved the winnerGavan Holohan celebrates his second penalty which proved the winner (Image: PA)

The travelling 4,300 Mariners fans - armed with inflatable haddocks - were then jubilant again as, after Caleta-Car was penalised for a foul on Danilo Orsi, Holohan stepped up again to score from the spot.

Caleta-Car volleyed the top-flight side back into the game after Southampton had brought on stars such as James-Ward Prowse.

But Grimsby held on for a famous victory, Saints having a late Theo Walcott strike disallowed for offside.

The Mariners will now prepare for their league encounter with Paul Simpson's side at Brunton Park on Saturday.

They sit 13 places and 20 points below the Cumbrians in the table.

The other FA Cup quarter-final ties, meanwhile, will see Manchester City at home to Burnley, Manchester United at home to Fulham and Sheffield United at home to Blackburn Rovers.