Flanker Mark Wilson has returned to the England starting line-up for their final Six Nations clash against Scotland.

Having come off the bench to earn his 12th international cap in Saturday's 57-14 success over Italy, the 29-year-old, who started his career at Penrith, comes in at number six in one of four changes.

Elsewhere, Jack Nowell replaces Joe Cokanasiga and Henry Slade comes in for Ben Te’o in the backs, while Ben Moon swaps with Ellis Genge in the front row.

Leicester Tigers' Ben Youngs will also pick up his 85th cap for his country on Saturday at Twickenham (5pm kick-off) and will become England’s most capped scrum-half of all time, moving ahead of Danny Care.

At the start of the weekend, Eddie Jones' team are second, a point behind leaders Wales who host Ireland, who are third, a point behind England and two behind Wales.

"It's the last week of the tournament so it's exciting," said head coach Jones.

"It will be a fascinating finish too, with the three teams that can win it, and we are playing against one of our most traditional foes in Scotland.

"Scotland are a difficult side - they are always at you, they play with a lot of enthusiasm and effort and have got a lot of attacking strings to their bow."

Carlisle's Chris Harris, meanwhile, is named on Scotland's bench as they look to defend the Calcutta Cup Trophy.

The 28-year-old, who began his career at Carlisle Rugby Club but can play for Scotland through his grandmother's heritage, returns from a calf injury he sustained while representing Newcastle Falcons.

Scotland come into the match on the back of an 18-11 loss to Wales.

"First of all, we have to build on the positive aspects of our performance from last weekend against Wales, when we were able to generate quick ball and build a lot of pressure on the opposition," said coach Gregor Townsend.

"The character and fitness the players displayed showed in the second half [showed] what the team is capable of against one of the best sides in the world. The next step is making that pressure count on the scoreboard, more regularly.

"Winning away from home tends to be achieved through an outstanding defensive performance and we are determined to deliver that this Saturday.

"At times against Wales, we weren’t aggressive or accurate enough so that has been a focus for us this week in training."