Steve Borthwick issued a call for "fight and desire" after naming his first England side for the Six Nations clash with Scotland.
The Carlisle-born head coach will hand a debut to Ollie Hassell-Collins in a team captained by Owen Farrell.
The Calcutta Cup clash at Twickenham on Saturday sees Borthwick at the helm for the first time since replacing Eddie Jones.
He said: "There are few fixtures in the rugby calendar that excite both players and supporters alike more than the annual Six Nations meeting of the Auld enemy as they battle for the honour of lifting the Calcutta Cup.
Steve Borthwick has named the England Men side to face Scotland on Saturday in round one of the Guinness Six Nations 🌹
— England Rugby (@EnglandRugby) February 2, 2023
"Another packed Twickenham will witness the start of the next chapter of English rugby in one of the most keenly contested tournaments in the world. There is no doubt this England team shares the supporters’ sense of eager anticipation.
"To a man, the players are determined to play with the commitment, fight and desire that is at the very heart of representing England, the sort of passion that our tremendous supporters rightly expect."
Borthwick's selection includes a first outing for Hassell-Collins at left wing, while Max Malins returns at right wing and Freddie Steward starts at full back.
Farrell will lead the side with Joe Marchant, Marcus Smith, Jack van Poortvliet, Ellis Genge, Kyle Sinckler, Jamie George, Maro Itoje, Ollie Chessum, Ben Curry, Lewis Ludlam and Alex Dombrandt also get the nod.
Carlisle's Chris Harris is among the replacements for Scotland.
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