The maker of OxyContin has agreed to pay 270 million US dollars (£204 million) to Oklahoma to settle allegations it helped set off the nation’s deadly opioid crisis with the aggressive marketing of the painkiller.

It is the first settlement to come out of the recent coast-to-coast wave of nearly 2,000 lawsuits against Stamford, Connecticut-based Purdue Pharma that threaten to push the company into bankruptcy and have stained the name of the Sackler family, whose members are among the world’s foremost philanthropists.

“The addiction crisis facing our state and nation is a clear and present danger, but we’re doing something about it today,” Oklahoma Attorney General Mike Hunter said.

Opioid Lawsuit Oklahoma
The giant has made billions of dollars from OxyContin but has been hit with over 1,000 lawsuits from state and local governments trying to hold the company responsible for the scourge of addiction (Toby Talbot/AP)

Nearly 200 million US dollars (£151 million) will go towards establishing the National Centre for Addiction Studies and Treatment at Oklahoma State University in Tulsa, while local governments will get 12.5 million US dollars (£9.5 million).

The Sackler family is responsible for 75 million US dollars (£57 million) of the settlement.

The deal comes two months before Oklahoma’s 2017 lawsuit against Purdue Pharma and other drug companies was set to become the first one in the recent barrage of litigation to go to trial.

The remaining defendants are still facing trial on May 28 for their role in creating what Mr Hunter called “this nightmarish epidemic” and “the worst public health crisis in our state and nation we’ve ever seen”.

Plaintiffs’ attorney Paul Hanly, who is not involved in the Oklahoma case but is representing scores of other governments, welcomed the deal, saying: “That suggests that Purdue is serious about trying to deal with the problem. Hopefully, this is the first of many.”

But some activists were furious, saying they were denied the chance to hold Purdue Pharma fully accountable in public, in front of a jury.

“This decision is a kick in the gut to our community,” said Ryan Hampton, who is recovering from opioid addiction.

“We deserve to have our day in court with Purdue. The parents, the families, the survivors deserve at least that. And Oklahoma stripped that from us today.”

He added: “We cannot allow Purdue to cut backroom deals with state attorneys general.”

An attorney for Purdue Pharma did not immediately return a call seeking comment.

Opioids, including heroin and prescription drugs like OxyContin, were a factor in a record 48,000 deaths across the US in 2017, according to the Centres for Disease Control and Prevention.

Oklahoma recorded about 400 opioid deaths that year. State officials have said that since 2009, more Oklahomans have died from opioids than in vehicle crashes.

Purdue Pharma introduced OxyContin in the 1990s and marketed it aggressively to doctors, making tens of billions of dollars from the drug.

But it has been hit with close to 2,000 lawsuits from state and local governments trying to hold the company responsible for the scourge of addiction.

The lawsuits accuse the company of downplaying the addiction risks and pushing doctors to increase dosages even as the dangers became known.

According to a court filing, Richard Sackler, then senior vice president responsible for sales, proudly told the audience at a launch party for OxyContin in 1996 that it would create a “blizzard of prescriptions that will bury the competition”.

Purdue Pharma has settled other lawsuits over the years, and three executives pleaded guilty to criminal charges in 2007.

But this is the first settlement to come out of the surge of litigation in the past few years that focuses largely on the company’s more recent conduct.