Flanker Mark Wilson will miss England's Rugby World Cup opener against Tonga this weekend.

The 29-year-old Cumbrian, who has recently been dealing with a knee injury, has not been selected in the England squad for Sunday morning's clash at Sapporo Dome (11.15am kick-off).

Carlisle-born Chris Harris, meanwhile, will start Scotland's World Cup opener against Ireland from the bench on Sunday.

For England, George Ford will start at fly-half and Owen Farrell at inside centre.

Head coach Eddie Jones has also picked the youthful combination of Tom Curry at blind-side and Sam Underhill at open-side.

Ahead of the match, Jones has declared England are ready for the twists and turns of the World Cup roller-coaster.

With his side for the opening encounter of England's title quest now chosen, Jones has turned his attention towards what awaits in Japan over the coming weeks.

He said: "The players have worked hard.

"Physically, I haven't seen them any better and, off the field, they've worked really hard to be a tight team.

"And that's going to be tested in the World Cup because the World Cup is like a roller-coaster.

"We are at the top of the ride now and we are looking down - everyone's nervous, everyone's excited. You go down the first slope and you're not sure if you are going to throw up or hang on.

"You've got to adapt to that and the players have equipped themselves to ride the roller-coaster because there's going to be some turns, there's going to be some accidents, there's going to be some fun.

"We want to enjoy all of those things that come along and the team's equipped to handle it."

But, despite former Penrith junior Wilson's absence for England, there could still be Cumbrian representation at the World Cup this weekend.

Former Carlisle Rugby Club man Harris will start on the bench for Gregor Townsend's team, while skipper Stuart McInally will lead out a side boasting 630 caps for their Pool A clash at Yokohama's International Stadium.

Exeter full-back Stuart Hogg and Saracens wing Sean Maitland return to the back three after missing this month's final warm-up Test against Georgia to partner Glasgow's Tommy Seymour.

Former skipper Greig Laidlaw joins playmaker Finn Russell at half-back, with centres Sam Johnson and Duncan Taylor the only backs to be reinstated from the 36-9 win over the Lelos.

Townsend said: "We've had a really productive week's preparation in Nagasaki ahead of our arrival in Tokyo, with our players adapting to the time zone and weather conditions out here in Japan.

"As we've got closer to the game, our training has been more about fine-tuning the hard work that's gone in over pre-season into a focus for Sunday's game.

"Our team has a lot of experience playing together in major games for Scotland, with a bench capable of making a difference when required.

"That cohesion, experience and leadership is very valuable in a build-up to a match of this magnitude, as well as during the 80 minutes on Sunday."