Five-times and defending champion Byrne was ruled out of action after suffering minor concussion in morning warm up at Donington Park at the opening round but is now fit and raring to go.
Byrne plans to reduce the points gap on rival Leon Haslam at his local track where he has won seven times, including at the corresponding meeting last year, where he took the first victory for the brand new Be Wiser Ducati Panigale R.
Meanwhile, Irwin is hoping to continue his brilliant start to the season when he followed up sixth place in the opening race of the season with a superb podium in the second outing at Donington Park on the factory-backed Be Wiser Ducati Panigale R.
The Ulsterman occupies fifth in the early season title race and is hoping to maintain that good form on the fast and furious Indy track over the bank holiday.
Byrne said: “I’m very hopeful of getting my title defence off to a far better start during round two at Brands Hatch than I did at Donington Park, that’s for sure!
“To be fair that shouldn’t be at all difficult seeing as a crash in warm up put me out of the round one races, so I’m a little behind having missed those races.
“But the plan is to make up for it in a big way this Bank Holiday weekend and where better than at my local circuit of Brands Hatch.
“I always enjoy racing there and am counting on plenty of support.
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