Police closed the A66 near Workington following a "serious" crash between a car and HGV.
The road was shut in both directions between Stainburn and the Great Clifton bypass - the Chapel Brow roundabout at Bridgefoot.
Police say there is one casualty - the male driver of the Ford Focus car.
The crash happened at about 7.20am today.
Paramedics, firefighters and police officers have all been at the scene.
There was a fire at the scene.
Two fire crews, from Workington and Maryport, attended and extinguished the blaze.
The road reopened at about 1.30pm.
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